Alprostadil: What It Is, How to Use It & What to Expect
If you’ve heard the name alprostadil but aren’t sure what it actually does, you’re in the right place. Alprostadil is a synthetic version of prostaglandin E1, a natural substance that relaxes blood vessels. Doctors mainly prescribe it for erectile dysfunction, but it also helps with certain heart problems and newborns with specific lung issues. Below we break down the basics so you can feel confident if this medication comes up in your treatment plan.
How Alprostadil Works and Who Uses It
Alprostadil works by widening blood vessels, which improves blood flow to targeted areas. In men with erectile dysfunction, better blood flow means a firmer, longer-lasting erection when the drug is applied directly to the penis. The medication can be given as an injection into the side of the penis or as a tiny suppository placed inside the urethra. Outside of sexual health, doctors sometimes use it for peripheral artery disease and to keep a newborn’s blood vessels open after birth.
Dosage Forms, Tips for Safe Use, and Common Side Effects
The two most common forms are the injection (often called Caverject or Edex) and the urethral suppository (known as Muse). Injections usually start at 2.5 micrograms, with the doctor adjusting the dose based on your response. Suppositories come in pre‑filled packets that dissolve inside the urethra; you typically use one packet before sexual activity.
Safety first: always follow the exact instructions your pharmacist gives you. Use a clean needle for each injection and rotate injection sites to avoid scar tissue. For suppositories, make sure the penis is clean and dry before insertion. Common side effects include mild pain at the injection site, a brief burning feeling with the suppository, or a slight headache. These usually fade within an hour.
If you notice prolonged pain, bruising, priapism (an erection lasting more than four hours), or any severe allergic reaction like swelling of the face, call your doctor right away. Those are signs that something’s wrong and need professional care.
When to talk to a doctor? If you have heart disease, low blood pressure, or bleeding disorders, let your provider know before starting alprostadil. Also, tell them about any medications you’re taking—especially blood thinners—as they can increase the risk of bruising.
Frequently asked questions
Can I use alprostadil with other ED drugs? Usually no; mixing it with PDE‑5 inhibitors like Viagra can cause unsafe drops in blood pressure.
How quickly does it work? Injections can produce an erection within 5–10 minutes, while suppositories may take a little longer, around 10–15 minutes.
Do I need a prescription? Yes. Alprostadil is only available with a doctor’s order because the dose must be tailored to you.
Bottom line: alprostadil can be an effective solution for many men who haven’t responded to oral pills, as long as it’s used correctly and under medical supervision. Keep these tips in mind, stay aware of side effects, and don’t hesitate to reach out to your healthcare provider if something feels off.
